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A significant distinction between 12-HHT and LTB4 chemical structure would be that the 12-HHT only includes a hydroxyl group at the C12 posture, when LTB4 has two hydroxyl groups, one particular in the C12 position and 1 in the C5 posture. Whether or not this distinction establishes the specificity of LTB1 and LTB2 is an interesting dilemma to talk